It depends in a controller pad sometimes is a real pain in the ass to press 2 buttons together
For example, on the XBOX, I had no problems with AB, CD and BD, but with AC and specially BC, I had to use macros, same with ABC, but just pressing A and the BC button I could do it fine
About macroing combos, is that even possible? I know that XBLA games had command combos, but all of them can't be used in XBOX LIVE matches, so I see no problems
Even using macros in an arcade stick is not that big deal for me, some people could had problems with it for whatever reason